Non Metastatic Cells 5, Protein NM23A Expressed In (NME5)

nm23-H5; RSPH23; NDK-H 5; IPIA-beta; Radial Spoke 23 Homolog; Inhibitor of p53-induced apoptosis-beta; Nucleoside diphosphate kinase homolog 5

SPN	N487
HGNC	7853
MGI	1922783
PubMed	22564704
UniProt	P56597

The nucleoside diphosphate (NDP) kinases are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the NM23 gene family. Munier et al. (1998) identified a novel homolog of NM23 in the EST database. They used PCR to clone the full coding sequence from several human cDNA libraries.

The NME5 gene encodes a 212-amino acid polypeptide with homology to the NDP kinases. Northern blot analysis detected abundant expression of a 1.1-kb mRNA in testis. In situ hybridization to testis revealed NME5 mRNA in the seminiferous tubules in a pattern consistent with stage-specific expression in germinal cells during spermatogenesis.

Reference

"A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells."
FEBS Lett. 434:289-294(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]