Hairy And Enhancer Of Split 1 (HES1)

HHL; HRY; BHLHB39; HL; Class B basic helix-loop-helix protein 39; Hairy-like protein

SPN	N443
HGNC	5192
MGI	104853
PubMed	23733337
RGD	62081
UniProt	Q14469
Wiki	HES1

HES1 belongs to a family of basic helix-loop-helix (bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. HES1 is a transcriptional repressor for a number of genes, but it can also function as a transcriptional activator. Increased expression of the gene encoding HES1 was required for quiescence to be reversible, because HES1 prevented both premature senescence and inappropriate differentiation in quiescent fibroblasts. In some human tumors, the HES1 pathway was activated, which allowed these cells to evade differentiation and irreversible cell cycle arrest. HES1 safeguards against irreversible cell cycle exit both during normal cellular quiescence and pathologically in the setting of tumorigenesis.

Reference

"Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy."
Genomics 20:56-61(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression."
Biochem. Biophys. Res. Commun. 301:250-257(2003) [PubMed] [Europe PMC] [Abstract]

"HES1 is a novel interactor of the Fanconi anemia core complex."
Blood 112:2062-2070(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]