STIP1 Homology And U-Box Containing Protein 1 (STUB1)
CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1; C Terminus Of HSC70-Interacting Protein; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP
The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation. CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. The deduced 303-amino acid proteinhas a molecular mass of 35 kD and contains three 34-amino acid TPR domains at its N terminus, a central domain rich in charged residues, and 2 potential nuclear localization signals. Human CHIP shares 97% and 53% amino acid identity with its mouse and Drosophila homologs, respectively, with the highest conservation in the 94 residues of the C terminus.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Hu01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Hu01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Hu01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Hu01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Hu01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Mu01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Mu01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Mu01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Mu01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Mu01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Ra01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Ra01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Ra01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Ra01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Ra01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Ca01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Ca01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Ca01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Ca01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Ca01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Po01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Po01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Po01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Po01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Po01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Bo01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Bo01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Bo01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Bo01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Bo01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Rb01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Rb01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Rb01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Rb01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Rb01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN302Mo01 | Recombinant STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN302Mo01 | Monoclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IP. |
| PAN302Mo01 | Polyclonal Antibody to STIP1 Homology And U-Box Containing Protein 1 (STUB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN302Mo01 | CLIA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | CLIA assay for Antigen Detection |
| ELN302Mo01 | ELISA Kit for STIP1 Homology And U-Box Containing Protein 1 (STUB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Characterization of human colon cancer antigens recognized by autologous antibodies."
Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
"Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions."
Mol. Cell. Biol. 19:4535-4545(1999) [PubMed] [Europe PMC] [Abstract]
"Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX."
Blood 100:2123-2131(2002) [PubMed] [Europe PMC] [Abstract]
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]