CDGSH Iron Sulfur Domain Protein 1 (CISD1)

ZCD1; mitoNEET; C10orf70; Zinc Finger,CDGSH-Type Domain 1

SPN	N266
HGNC	30880
MGI	1261855
RGD	1309529
UniProt	Q9NZ45

CISD1 is a member of the CDGSH domain-containing family and may play a role in the regulation of mitochondrial oxidative capacity. The deduced 108-amino acid protein has a calculated molecular mass of 12.2 kD and contains an N-terminal signal sequence and a C-terminal CDGSH domain, flanked by 2 additional cysteines. The CDGSH domain contains a consensus sequence shared by CISD1, CISD2, and CISD3 . Immunofluorescence studies localized CISD1 to the mitochondria. RT-PCR analysis of mouse tissues detected ubiquitous expression with highest expression in heart. Immunohistochemical staining of mouse tissues detected Cisd1 in many tissues, including liver, adipose tissue, skeletal muscle, and heart. Staining was particularly intense in cells lining the ducts and ventricles.

Reference

"CISD1 codifies a mitochondrial protein upregulated by the CFTR channel."
Biochem. Biophys. Res. Commun. 365:856-862(2008) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster."
J. Biol. Chem. 282:23745-23749(2007) [PubMed] [Europe PMC] [Abstract]

"MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity."
Proc. Natl. Acad. Sci. U.S.A. 104:5318-5323(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2."
J. Mol. Biol. 392:143-153(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."
Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]

"Crystallographic studies of human MitoNEET."
J. Biol. Chem. 282:33242-33246(2007) [PubMed] [Europe PMC] [Abstract]

"MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone."
Proc. Natl. Acad. Sci. U.S.A. 104:14342-14347(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins."
Proc. Natl. Acad. Sci. U.S.A. 104:14640-14645(2007) [PubMed] [Europe PMC] [Abstract]