Complement Factor H Related Protein 5 (CFHR5)
CFHL5; FHR-5; FHR5
CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Hu01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Hu01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Hu01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Hu01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Hu01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Mu01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Mu01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Mu01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Mu01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Mu01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Ra01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Ra01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Ra01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Ra01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Ra01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Ca01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Ca01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Ca01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Ca01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Ca01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Po01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Po01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Po01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Po01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Po01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Bo01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Bo01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Bo01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Bo01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Bo01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Rb01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Rb01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Rb01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Rb01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Rb01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN057Mo01 | Recombinant Complement Factor H Related Protein 5 (CFHR5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN057Mo01 | Monoclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IP. |
| PAN057Mo01 | Polyclonal Antibody to Complement Factor H Related Protein 5 (CFHR5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN057Mo01 | CLIA Kit for Complement Factor H Related Protein 5 (CFHR5) | CLIA assay for Antigen Detection |
| ELN057Mo01 | ELISA Kit for Complement Factor H Related Protein 5 (CFHR5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human factor H-related protein 5 (FHR-5). A new complement-associated protein."
J. Biol. Chem. 276:6747-6754(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis."
Lancet 376:794-801(2010) [PubMed] [Europe PMC] [Abstract]
"Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency."
Am. J. Kidney Dis. 60:121-125(2012) [PubMed] [Europe PMC] [Abstract]
"Dimerization of complement factor H-related proteins modulates complement activation in vivo."
Proc. Natl. Acad. Sci. U.S.A. 110:4685-4690(2013) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]
"Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene."
J. Hum. Genet. 57:459-464(2012) [PubMed] [Europe PMC] [Abstract]