CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD)
RAIDD; RIP-Associated ICH1/CED3-Homologous Protein With Death Domain; Caspase and RIP adapter with death domain; Death domain-containing protein CRADD
CRADD is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.RAIDD specifically bound RIP, but not the DD-containing receptors FAS or TNFR1, or the DD-containing receptor-associated proteins FADD or TRADD. However, coimmunoprecipitation studies indicated that TNFR1 complexed with RAIDD in the presence of TRADD and RIP, and through RAIDD, ICH1 was recruited to the signaling complex. Overexpression of RAIDD in mammalian cells induced apoptosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Hu01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Hu01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Hu01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Hu01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Hu01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Mu01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Mu01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Mu01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Mu01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Mu01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Ra01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Ra01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Ra01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Ra01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Ra01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Ca01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Ca01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Ca01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Ca01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Ca01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Po01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Po01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Po01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Po01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Po01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Bo01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Bo01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Bo01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Bo01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Bo01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Rb01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Rb01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Rb01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Rb01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Rb01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN011Mo01 | Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN011Mo01 | Monoclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IP. |
| PAN011Mo01 | Polyclonal Antibody to CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN011Mo01 | CLIA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | CLIA assay for Antigen Detection |
| ELN011Mo01 | ELISA Kit for CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP."
Cancer Res. 57:615-619(1997) [PubMed] [Europe PMC] [Abstract]
"RAIDD is a new 'death' adaptor molecule."
Nature 385:86-89(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Science 304:843-846(2004) [PubMed] [Europe PMC] [Abstract]
"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage."
Oncogene 25:5683-5692(2006) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment."
Cell 94:171-180(1998) [PubMed] [Europe PMC] [Abstract]
"Genetic mapping and exome sequencing identify variants associated with five novel diseases."
PLoS ONE 7:E28936-E28936(2012) [PubMed] [Europe PMC] [Abstract]