Deltex Homolog 1 (DTX1)
hDx-1; E3 ubiquitin-protein ligase DTX1
Expression of DTX1 partially inhibited transactivation of a CSL (RBPSUH)-dependent luciferase reporter by activated intracellular NOTCH1 (ICN1) in human and mouse cells. The N terminus of DTX1, which directly interacts with the NOTCH1 ankyrin repeats, inhibited transactivation by ICN1 possessing the ankyrin repeats, probably by inhibiting recruitment of coactivators to the C-terminal transactivation domain of NOTCH1.the 620-amino acid DTX1 protein contains an N-terminal domain predicted to associate with Notch ankyrin repeats, followed by a proline-rich region with potential SH3 domain-binding sites and a C-terminal domain that includes a classic RING-H2 finger motif. DTX1 functioned as a ubiquitin E3 ligase. It showed highest ubiquitination activity in conjunction with the E2 enzyme UBCH5A (UBE2D1).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Hu01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Hu01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Hu01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Hu01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Hu01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Mu01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Mu01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Mu01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Mu01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Mu01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Ra01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Ra01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Ra01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Ra01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Ra01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Ca01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Ca01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Ca01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Ca01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Ca01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Po01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Po01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Po01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Po01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Po01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Bo01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Bo01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Bo01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Bo01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Bo01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Rb01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Rb01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Rb01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Rb01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Rb01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM935Mo01 | Recombinant Deltex Homolog 1 (DTX1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM935Mo01 | Monoclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IP. |
| PAM935Mo01 | Polyclonal Antibody to Deltex Homolog 1 (DTX1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM935Mo01 | CLIA Kit for Deltex Homolog 1 (DTX1) | CLIA assay for Antigen Detection |
| ELM935Mo01 | ELISA Kit for Deltex Homolog 1 (DTX1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human deltex is a conserved regulator of Notch signalling."
Nat. Genet. 19:74-78(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1."
Immunity 16:231-243(2002) [PubMed] [Europe PMC] [Abstract]
"Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor."
J. Biol. Chem. 276:45031-45040(2001) [PubMed] [Europe PMC] [Abstract]
"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development."
Immunity 18:675-685(2003) [PubMed] [Europe PMC] [Abstract]
"The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
"Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains."
EMBO Rep. 7:1147-1153(2006) [PubMed] [Europe PMC] [Abstract]
"The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation."
PLoS Biol. 8:E1000545-E1000545(2010) [PubMed] [Europe PMC] [Abstract]