Eukaryotic Translation Initiation Factor 6 (EIF6)

ITGB4BP; CAB; p27BBP; Integrin Beta 4 Binding Protein; B4 integrin interactor

SPN	M896
HGNC	6159
MGI	1196288
PubMed	18327211
RGD	1305373
UniProt	P56537
Wiki	EIF6

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains.

EIF6binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.

Reference

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Gene 266:35-43(2001) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell. Biol. 23:6187-6199(2003) [PubMed] [Europe PMC] [Abstract]

"Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly."
Nature 426:579-584(2003) [PubMed] [Europe PMC] [Abstract]

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"Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6."
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