Filamin Binding LIM Protein 1 (FBLIM1)
CAL; FBLP-1; FBLP1; Migfilin; Mitogen-inducible 2-interacting protein
FBLIM1encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Hu01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Hu01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Hu01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Hu01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Hu01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Mu01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Mu01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Mu01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Mu01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Mu01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Ra01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Ra01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Ra01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Ra01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Ra01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Ca01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Ca01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Ca01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Ca01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Ca01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Po01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Po01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Po01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Po01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Po01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Bo01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Bo01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Bo01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Bo01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Bo01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Rb01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Rb01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Rb01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Rb01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Rb01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM869Mo01 | Recombinant Filamin Binding LIM Protein 1 (FBLIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM869Mo01 | Monoclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IP. |
| PAM869Mo01 | Polyclonal Antibody to Filamin Binding LIM Protein 1 (FBLIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM869Mo01 | CLIA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | CLIA assay for Antigen Detection |
| ELM869Mo01 | ELISA Kit for Filamin Binding LIM Protein 1 (FBLIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation."
Cell 113:37-47(2003) [PubMed] [Europe PMC] [Abstract]
"A new member of the LIM protein family binds to filamin B and localizes at stress fibers."
J. Biol. Chem. 278:12175-12181(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Structural basis of the migfilin-filamin interaction and competition with integrin beta tails."
J. Biol. Chem. 283:35154-35163(2008) [PubMed] [Europe PMC] [Abstract]
"Migfilin, a molecular switch in regulation of integrin activation."
J. Biol. Chem. 284:4713-4722(2009) [PubMed] [Europe PMC] [Abstract]