Junctional Adhesion Molecule 3 (JAM3)

JAM-C; JAMC

SPN	M750
HGNC	15532
MGI	1933825
PubMed	12208882
RGD	1303248
UniProt	Q9BX67
Wiki	JAM3

JAM3 is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.Widely expressed. Highest expression in placenta, brain and kidney.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions.

Reference

"Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor."
J. Biol. Chem. 276:45826-45832(2001) [PubMed] [Europe PMC] [Abstract]

"Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members."
Blood 98:3699-3707(2001) [PubMed] [Europe PMC] [Abstract]

"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]

"Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis."
Genomics 79:475-478(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
Trends Immunol. 24:327-334(2003) [PubMed] [Europe PMC] [Abstract]

"JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]

"Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth."
Cancer Res. 65:5703-5710(2005) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
Am. J. Hum. Genet. 87:882-889(2010) [PubMed] [Europe PMC] [Abstract]

"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
J. Immunol. 185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
Hum. Mutat. 34:498-505(2013) [PubMed] [Europe PMC] [Abstract]