Tricellulin (TRIC)
MARVELD2; DFNB49; MARVD2; MRVLDC2; MARVEL Domain Containing Protein 2; Deafness,Autosomal Recessive 49
MARVELD2, or tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular contacts.The 555-amino acid protein contains cytoplasmic N and C termini, 2 transmembrane domains, and 2 extracellular loops. Northern blot analysis detected high expression of Tric in epithelium-derived tissues, including small intestine, kidney, and lung. Western blot analysis of mouse epithelial cell lines revealed an approximately 66-kD protein, as well as larger phosphorylated intracellular forms. Immunofluorescence microscopy showed expression of Tric predominantly at tricellular contacts where occludin (OCLN)-positive bicellular TJs converged. Tric-positive structures appeared as short rods through confocal microscopy.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Hu01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Hu01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Hu01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Hu01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Hu01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Mu01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Mu01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Mu01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Mu01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Mu01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Ra01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Ra01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Ra01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Ra01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Ra01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Ca01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Ca01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Ca01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Ca01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Ca01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Po01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Po01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Po01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Po01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Po01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Bo01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Bo01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Bo01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Bo01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Bo01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Rb01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Rb01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Rb01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Rb01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Rb01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM681Mo01 | Recombinant Tricellulin (TRIC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM681Mo01 | Monoclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IP. |
| PAM681Mo01 | Polyclonal Antibody to Tricellulin (TRIC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM681Mo01 | CLIA Kit for Tricellulin (TRIC) | CLIA assay for Antigen Detection |
| ELM681Mo01 | ELISA Kit for Tricellulin (TRIC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells."
J. Cell Biol. 171:939-945(2005) [PubMed] [Europe PMC] [Abstract]
"Tricellulin is a tight-junction protein necessary for hearing."
Am. J. Hum. Genet. 79:1040-1051(2006) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]