Wingless Type MMTV Integration Site Family, Member 4 (WNT4)

SPN	M576
HGNC	12783
MGI	98957
PubMed	17976036
RGD	621348
UniProt	P56705

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT4 is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Hu01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Hu01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Hu01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Hu01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Hu01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Mu01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Mu01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Mu01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Mu01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Mu01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Ra01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Ra01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Ra01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Ra01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Ra01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Ca01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Ca01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Ca01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Ca01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Ca01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Po01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Po01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Po01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Po01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Po01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Bo01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Bo01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Bo01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Bo01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Bo01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Rb01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Rb01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Rb01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Rb01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Rb01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM576Mo01	Recombinant Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM576Mo01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IP.
Antibodies	PAM576Mo01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	WB; IHC; ICC; IF.
Assay Kits	CLM576Mo01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	CLIA assay for Antigen Detection
Assay Kits	ELM576Mo01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 4 (WNT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans."
Am. J. Hum. Genet. 68:1102-1109(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]

"A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman."
N. Engl. J. Med. 351:792-798(2004) [PubMed] [Europe PMC] [Abstract]

"WNT4 deficiency-a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report."
Hum. Reprod. 22:224-229(2007) [PubMed] [Europe PMC] [Abstract]

"SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4."
Am. J. Hum. Genet. 82:39-47(2008) [PubMed] [Europe PMC] [Abstract]

"Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study."
J. Clin. Endocrinol. Metab. 93:895-900(2008) [PubMed] [Europe PMC] [Abstract]