UL16 Binding Brotein 2 (ULBP2)

N2DL2; RAET1H; NKG2D Ligand 2; Retinoic acid early transcript 1H; NKG2D ligand 2

SPN	M511
HGNC	14894
PubMed	21764762
UniProt	Q9BZM5
Wiki	ULBP2

Human cytomegalovirus (CMV) frequently infects young people and persists for the lifetime of the individual in a latent state, due in part to downregulation of major histocompatibility (MHC) class I expression and evasion of T cell-mediated immunity, with occasional asymptomatic episodes of viral shedding. ULBP2 has a putative glycosylphosphatidylinositol (GPI) linkage to the membrane. Enzymatic analysis confirmed that the ULBPs are indeed GPI-linked at the cell surface. RT-PCR analysis detected ULBP expression in T, B, and erythroleukemia cell lines and in a wide range of tissues; ULBP2, however, was not detected in the Namalwa Burkitt lymphoma cell line. Expression was upregulated in colon and stomach tumors and downregulated in kidney tumors. FACS analysis demonstrated that protein expression generally correlated with message expression.

Reference

"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."
Immunity 14:123-133(2001) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
J. Immunol. 168:671-679(2002) [PubMed] [Europe PMC] [Abstract]

"Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."
J. Exp. Med. 197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]

"NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer."
Tissue Antigens 61:335-343(2003) [PubMed] [Europe PMC] [Abstract]