N-myc Downstream Regulated Gene 2 (NDRG2)

SYLD; N-myc downstream-regulated gene 2 protein

SPN	M486
HGNC	14460
MGI	1352498
PubMed	23056173
RGD	621874
UniProt	Q9UN36
Wiki	NDRG2

NDRG2 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Kalaydjieva et al. (2000) identified the homologous human genes, which they referred as NDRG2 and NDRG3. Kalaydjieva et al. (2000) stated that the 3 known human NDRG proteins show considerable homology: 54% amino acid sequence identity between NDRG1 and NDRG2, 67% between NDRG1 and NDRG3, and 58% between NDRG2 and NDRG3.

Reference

"Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart."
Genomics 73:86-97(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family."
Mol. Cell. Biochem. 229:35-44(2002) [PubMed] [Europe PMC] [Abstract]

"N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation."
Int. J. Cancer 106:342-347(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells."
FEBS Lett. 553:413-418(2003) [PubMed] [Europe PMC] [Abstract]

"NDRG2: a novel Alzheimer's disease associated protein."
Neurobiol. Dis. 16:48-58(2004) [PubMed] [Europe PMC] [Abstract]

"NDRG2 expression and mutation in human liver and pancreatic cancers."
World J. Gastroenterol. 10:3518-3521(2004) [PubMed] [Europe PMC] [Abstract]

"Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma."
Cancer Res. 65:7121-7126(2005) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor."
J. Biol. Chem. 286:12450-12460(2011) [PubMed] [Europe PMC] [Abstract]