NLR Family, CARD Domain Containing Protein 4 (NLRC4)

CARD12; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF; Ice protease-activating factor; Caspase Recruitment Domain Family Member 12; NOD-Like Receptor C4

SPN	M444
HGNC	16412
MGI	3036243
PubMed	22885697
RGD	1309831
UniProt	Q9NPP4
Wiki	NLRC4

The deduced full-length 1,024-amino acid protein, termed CLANA, contains the CARD, LRR, and NACHT domains, including 4 LRRs, whereas the 359-residue protein, termed CLANB, has the CARD spliced directly to the LRRs. The 156- and 92-amino acid proteins, termed CLANC and CLAND, contain only the CARD and regions with no homology to known motifs. Northern blot analysis revealed nearly ubiquitous expression of a 1.5-kb transcript corresponding to CARDB, with highest levels in lung and spleen. A 3.5-kb transcript corresponding to CLANA was detected primarily in lung. RT-PCR analysis showed ubiquitous expression of CLANB, while CLANA was restricted to lung, colon, brain, prostate, spleen, and leukocytes, predominantly monocytes.

Reference

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Biochem. Biophys. Res. Commun. 284:77-82(2001) [PubMed] [Europe PMC] [Abstract]

"CLAN, a novel human CED-4-like gene."
Genomics 75:77-83(2001) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 276:28309-28313(2001) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses."
Biochem. J. 381:213-219(2004) [PubMed] [Europe PMC] [Abstract]

"Novel role of PKR in inflammasome activation and HMGB1 release."
Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]

"An inherited mutation in NLRC4 causes autoinflammation in human and mice."
J. Exp. Med. 211:2385-2396(2014) [PubMed] [Europe PMC] [Abstract]

"Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation."
Nat. Genet. 46:1135-1139(2014) [PubMed] [Europe PMC] [Abstract]

"An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome."
Nat. Genet. 46:1140-1146(2014) [PubMed] [Europe PMC] [Abstract]