Inositol Polyphosphate-5-Phosphatase 145kDa (INPP5D)

SHIP; SHIP1; SIP-145; hp51CN; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 1; SH2 domain-containing inositol 5'-phosphatase 1

SPN	M368
HGNC	6079
MGI	107357
PubMed	8643691
RGD	2914
UniProt	Q92835
Wiki	INPP5D

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Reference

"Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase."
Biochem. Biophys. Res. Commun. 225:243-249(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation."
Blood 88:2833-2840(1996) [PubMed] [Europe PMC] [Abstract]

"Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2."
Curr. Biol. 6:438-445(1996) [PubMed] [Europe PMC] [Abstract]

"The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood."
Blood 89:1876-1885(1997) [PubMed] [Europe PMC] [Abstract]

"Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl."
Blood 89:2745-2756(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis."
J. Immunol. 162:5719-5727(1999) [PubMed] [Europe PMC] [Abstract]

"The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells."
Cell. Signal. 12:317-326(2000) [PubMed] [Europe PMC] [Abstract]

"Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors."
J. Immunol. 169:5441-5450(2002) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils."
Cell. Signal. 18:2022-2032(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the human SHIP SH2 domain."
Submitted (APR-2008) to the PDB data bank

"Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia."
Leukemia 17:1-8(2003) [PubMed] [Europe PMC] [Abstract]