Resistin Like Beta (RETNLb)

XCP2; FIZZ2; HXCP2; CCRG; RETNL2; RELMb; Foundin In Flammatory Zone 2; Colon and small intestine-specific cysteine-rich protein; Colon carcinoma-related gene protein

SPN	M267
HGNC	20388
MGI	2667763
PubMed	12601307
RGD	1624215
UniProt	Q9BQ08
Wiki	RETNLB

The 111-amino acid FIZZ2 protein, which shows 59% sequence identity to mouse Fizz2 and 47% identity to human FIZZ3, shares an N-terminal signal peptide and a C-terminal stretch of 10 cysteine residues with identical spacing with other FIZZ family members. Strong expression of mouse Fizz2 mRNA was found in the adult colon in the mucosal crypt epithelial cells. Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels. This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase. The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.

Reference

"Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice."
Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract]

"A family of tissue-specific resistin-like molecules."
Proc. Natl. Acad. Sci. U.S.A. 98:502-506(2001) [PubMed] [Europe PMC] [Abstract]

"Bioinformatics based discovery of a novel factor with apparent specificity to colon cancer."
In Vivo 16:239-248(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]