REV1 Homolog (REV1)

REV1L; aIBP80; Alpha Integrin Binding Protein 80; Rev1-like terminal deoxycytidyl transferase

SPN	M266
HGNC	14060
MGI	1929074
PubMed	22266823
RGD	1306715
UniProt	Q9UBZ9
Wiki	REV1

The Rev1 contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.REV1L protein is a deoxycytidyl transferase that specifically inserts a dCMP residue opposite a DNA template G. In addition, the human REV1L transferase is able to insert a dCMP opposite a DNA template apurinic/apyrimidinic (AP) site or a uracil residue. The authors suggested that the REV1L transferase may play a critical role during mutagenic translesion DNA synthesis, bypassing a template AP site in human cells.

Reference

"The human REV1 gene codes for a DNA template-dependent dCMP transferase."
Nucleic Acids Res. 27:4468-4475(1999) [PubMed] [Europe PMC] [Abstract]

"The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light."
Proc. Natl. Acad. Sci. U.S.A. 97:4186-4191(2000) [PubMed] [Europe PMC] [Abstract]

"Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain."
J. Biol. Chem. 276:15051-15058(2001) [PubMed] [Europe PMC] [Abstract]

"Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7."
J. Biol. Chem. 276:35644-35651(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains."
FEBS Lett. 445:351-355(1999) [PubMed] [Europe PMC] [Abstract]

"Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins."
J. Biol. Chem. 278:12356-12360(2003) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1."
J. Biol. Chem. 285:12299-12307(2010) [PubMed] [Europe PMC] [Abstract]

"Regulation of Rev1 by the Fanconi anemia core complex."
Nat. Struct. Mol. Biol. 19:164-170(2012) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the BRCT domain from human DNA repair protein REV1."
Submitted (AUG-2007) to the PDB data bank