SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2)
SCO1L
The deduced human SCO2 protein of 266 amino acids predicts an N-terminal mitochondrial targeting presequence of 41 amino acids. Human and yeast SCO polypeptides share the greatest identity in a core region, which lies between glycine-102 and glycine-242 in human SCO2. In this region the amino acid identity between the 2 human proteins (54%) is less than that between the 2 yeast proteins (73%).
Moreover, human SCO2 and SCO1 show similar divergence from both yeast proteins suggesting that the 2 human genes are not orthologous to the 2 yeast genes, but rather are paralogous genes. Northern blot analysis detected SCO2 expression as a 0.9-kb transcript in all 12 human tissues examined, with strongest signals in heart, skeletal muscle, brain, liver, and kidney.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Hu01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Hu01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Hu01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Hu01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Hu01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Mu01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Mu01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Mu01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Mu01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Mu01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Ra01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Ra01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Ra01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Ra01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Ra01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Ca01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Ca01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Ca01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Ca01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Ca01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Po01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Po01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Po01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Po01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Po01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Bo01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Bo01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Bo01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Bo01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Bo01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Rb01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Rb01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Rb01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Rb01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Rb01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM207Mo01 | Recombinant SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM207Mo01 | Monoclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IP. |
| PAM207Mo01 | Polyclonal Antibody to SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM207Mo01 | CLIA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | CLIA assay for Antigen Detection |
| ELM207Mo01 | ELISA Kit for SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene."
Nat. Genet. 23:333-337(1999) [PubMed] [Europe PMC] [Abstract]
"Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
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Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A structural characterization of human SCO2."
Structure 15:1132-1140(2007) [PubMed] [Europe PMC] [Abstract]
"Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency."
Hum. Mol. Genet. 9:795-801(2000) [PubMed] [Europe PMC] [Abstract]
"Homozygosity (E140K) in SCO2 causes delayed infantile onset of cardiomyopathy and neuropathy."
Neurology 57:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
"Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype."
Am. J. Med. Genet. A 125A:310-314(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations in SCO2 are associated with autosomal-dominant high-grade myopia."
Am. J. Hum. Genet. 92:820-826(2013) [PubMed] [Europe PMC] [Abstract]