Secreted And Transmembrane Protein 1 (SECTM1)

K12; Type 1a Transmembrane Protein

SPN	M203
HGNC	10707
MGI	2384805
PubMed	9480746
RGD	1305973
UniProt	Q8WVN6
Wiki	SECTM1

SECTM1 encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.

The predicted 248-amino acid K12 protein has the hydropathic characteristics of a type 1a transmembrane protein, which is defined by an extracellular N terminus and a cleaved signal peptide. The authors demonstrated that the K12 protein behaves biochemically as an integral membrane protein. Using immunofluorescence, they localized K12 to the Golgi. Western blotting showed that the K12 protein migrates as a cluster of bands at 27 kD. In addition, an approximately 20-kD soluble form of K12 is secreted by cells.

Reference

"Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms."
Genomics 47:327-340(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma."
J. Clin. Immunol. 25:41-49(2005) [PubMed] [Europe PMC] [Abstract]