Splicing Factor 3B Subunit 3 (SF3B3)

RSE1; SAP130; SF3b130; STAF130; Spliceosome-associated protein 130; Pre-mRNA-splicing factor SF3b 130 kDa subunit

SPN	M183
HGNC	10770
MGI	1289341
PubMed	23359068
RGD	1311636
UniProt	Q15393
Wiki	SF3B3

SF3B3 encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Reference

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