SKI Like Oncogene (SKIL)
SNO; SnoN; SnoA
The mouse Sno gene expresses 2 isoforms, SnoN and SnoN2, that are different from each other in a location downstream of the site of alternative splicing previously described in the human SNO gene. SnoN2 is missing a 138-bp coding segment present in mouse SnoN and human SNON. TGFB induces activation and nuclear translocation of SMAD2, SMAD3, and SMAD4. SMAD3 causes degradation of SnoN, allowing a SMAD2/SMAD4 complex to activate TGFB target genes. To initiate a negative feedback mechanism that permits a precise and timely regulation of TGFB signaling, TGFB also induces an increased expression of SnoN at a later stage, which in turn binds to SMAD heteromeric complexes and shuts off TGFB signaling.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Hu01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Hu01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Hu01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Hu01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Hu01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Mu01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Mu01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Mu01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Mu01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Mu01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Ra01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Ra01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Ra01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Ra01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Ra01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Ca01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Ca01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Ca01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Ca01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Ca01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Po01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Po01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Po01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Po01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Po01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Bo01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Bo01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Bo01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Bo01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Bo01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Rb01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Rb01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Rb01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Rb01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Rb01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM165Mo01 | Recombinant SKI Like Oncogene (SKIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM165Mo01 | Monoclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IP. |
| PAM165Mo01 | Polyclonal Antibody to SKI Like Oncogene (SKIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM165Mo01 | CLIA Kit for SKI Like Oncogene (SKIL) | CLIA assay for Antigen Detection |
| ELM165Mo01 | ELISA Kit for SKI Like Oncogene (SKIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of human cDNA clones of ski and the ski-related gene, sno."
Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
"Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno."
Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract]
"Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
"Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."
Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]