Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1)
OF; PU.1; SFPI1; SPI-1; SPI-A; SPI-1 Proto-Oncogene; Hematopoietic Transcription Factor PU.1; 31 kDa Transforming Protein
SPI1 encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.The genomic locus was called Spi1, for SFFV proviral integration. Rearrangements due to SFFV integration were found in 95% of the erythroid tumors studied. A 4.0-kb mRNA was detected in rearranged tumors. The evolutionary conservation of the SPI1 locus was examined in cellular DNAs from various vertebrate species.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Hu01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Hu01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Hu01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Hu01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Hu01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Mu01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Mu01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Mu01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Mu01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Mu01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Ra01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Ra01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Ra01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Ra01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Ra01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Ca01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Ca01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Ca01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Ca01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Ca01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Po01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Po01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Po01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Po01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Po01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Bo01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Bo01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Bo01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Bo01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Bo01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Rb01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Rb01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Rb01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Rb01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Rb01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM124Mo01 | Recombinant Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM124Mo01 | Monoclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IP. |
| PAM124Mo01 | Polyclonal Antibody to Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM124Mo01 | CLIA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | CLIA assay for Antigen Detection |
| ELM124Mo01 | ELISA Kit for Spleen Focus Forming Virus Proviral Integration Oncogene (SPI1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors."
Oncogene 5:663-668(1990) [PubMed] [Europe PMC] [Abstract]
Erratum
Oncogene 5:1611-1612(1990)
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
"Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
Mol. Cell. Biol. 19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]
"The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction."
J. Biol. Chem. 282:6473-6483(2007) [PubMed] [Europe PMC] [Abstract]
"BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]