Steroid 5 Alpha Reductase 1 (SRD5a1)
3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1
SRD5a1 isozyme is not detectable in the fetus, is transiently expressed in newborn skin and scalp, and is permanently expressed in skin from the time of puberty. There was no qualitative difference in 5-alpha-reductase type 1 expression between adult balding versus nonbalding scalp. The type 2 isozyme was transiently expressed in skin and scalp of newborns. Type 2 is the predominant isozyme detectable in fetal genital skin, in male accessory sex organs, and in the prostate, including benign prostatic hyperplasia and prostate adenocarcinoma tissues. These results were considered consistent with 5-alpha-reductase type 1 being responsible for the virilization in type 2-deficient subjects during puberty and suggested that the type 2 isozyme may be an initiating factor in the development of male pattern baldness.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Hu01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Hu01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Hu01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Hu01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Hu01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Mu01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Mu01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Mu01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Mu01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Mu01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Ra01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Ra01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Ra01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Ra01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Ra01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Ca01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Ca01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Ca01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Ca01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Ca01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Po01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Po01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Po01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Po01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Po01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Bo01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Bo01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Bo01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Bo01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Bo01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Rb01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Rb01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Rb01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Rb01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Rb01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM111Mo01 | Recombinant Steroid 5 Alpha Reductase 1 (SRD5a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM111Mo01 | Monoclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IP. |
| PAM111Mo01 | Polyclonal Antibody to Steroid 5 Alpha Reductase 1 (SRD5a1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM111Mo01 | CLIA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | CLIA assay for Antigen Detection |
| ELM111Mo01 | ELISA Kit for Steroid 5 Alpha Reductase 1 (SRD5a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed] [Europe PMC] [Abstract]
"Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."
Genomics 11:1102-1112(1991) [PubMed] [Europe PMC] [Abstract]
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."
Pflugers Arch. 442:R187-R189(2001) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]