Transformer 2 Beta (TRA2b)

SRFS10; Htra2-beta; TRA2-BETA; TRA2B; Splicing Factor,Arginine/Serine-Rich 10; Transformer-2 protein homolog B

SPN	M008
HGNC	10781
MGI	106016
PubMed	9790768
RGD	619886
UniProt	P62995
Wiki	TRA2B

TRA2-beta gene contains 10 exons and spans 21 kb. RT-PCR and analysis of TRA2-beta cDNAs in the EST database indicated that 5 different TRA2-beta RNA isoforms are generated by alternative splicing.

TRA2-beta-1 is a nuclear protein that colocalizes with SC35 in a speckled pattern. It interacts with several SR proteins in yeast. A second isoform, named TRA2-beta-2, is generated by alternative splicing. This isoform gives rise to a truncated protein without an SR domain. Both isoforms are evenly distributed throughout adult rat tissue. The ratio of these 2 isoforms changes after stimulation of primary human T-cell and primary rat spleen cell cultures, indicating that alternative splicing is involved in the regulation of TRA2-beta activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Hu01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Hu01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Hu01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Hu01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Hu01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Mu01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Mu01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Mu01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Mu01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Mu01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Ra01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Ra01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Ra01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Ra01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Ra01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Ca01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Ca01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Ca01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Ca01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Ca01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Po01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Po01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Po01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Po01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Po01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Bo01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Bo01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Bo01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Bo01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Bo01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Rb01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Rb01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Rb01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Rb01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Rb01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM008Mo01	Recombinant Transformer 2 Beta (TRA2b)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM008Mo01	Monoclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IP.
Antibodies	PAM008Mo01	Polyclonal Antibody to Transformer 2 Beta (TRA2b)	WB; IHC; ICC; IF.
Assay Kits	CLM008Mo01	CLIA Kit for Transformer 2 Beta (TRA2b)	CLIA assay for Antigen Detection
Assay Kits	ELM008Mo01	ELISA Kit for Transformer 2 Beta (TRA2b)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing."
DNA Cell Biol. 16:679-690(1997) [PubMed] [Europe PMC] [Abstract]

"Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform."
Genomics 53:191-202(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]