Family With Sequence Similarity 3, Member D (FAM3D)

EF7; OIT1

SPN	L962
HGNC	18665
MGI	1201784
PubMed	22226334
RGD	1305512
UniProt	Q96BQ1
Wiki	FAM3D

By searching an EST database for sequences similar to FAM3A, followed by RT-PCR of placenta mRNA, Zhu et al. (2002) cloned FAM3D. The deduced 224-amino acid protein contains an N-terminal signal peptide. The authors predicted that FAM3D forms a 4-helix bundle, and 3-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3D expression at a high level in placenta and at a lower level in small intestine.

The International Radiation Hybrid Mapping Consortium mapped the FAM3D gene to chromosome 3 .

Reference

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J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]