Phospholipase A2, Group IVD (PLA2G4D)

cPLA2delta; Cytosolic phospholipase A2 delta

SPN	L665
HGNC	30038
MGI	1925640
PubMed	16213696
RGD	1593372
UniProt	Q86XP0

PLA2G4D acts as a calcium-dependent phospholipase A2 enzyme with a lineolic acid-specific activity. Using in situ hybridization and immunohistochemistry of normal and psoriatic skin, as well as skin from patients with inflammatory skin conditions such as atopic dermatitis and mycosis fungoides, the authors determined that PLA2G4D mRNA and protein display a strong specific expression in the upper epidermis in psoriatic skin, and not in lower epidermis and dermis.

A similar distribution of PLA2G4D expression, at decreased levels, was detected in the upper epidermis of patients with other inflammatory skin conditions, while PLA2G4D mRNA and protein were not detected in normal adult skin.PLA2G4D expression is specifically upregulated in the upper epidermis of patients with inflammatory skin diseases.

Reference

"Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin."
J. Biol. Chem. 279:12890-12897(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A family based study of the genetic association between the PLA2G4D gene and schizophrenia."
Prostaglandins Leukot. Essent. Fatty Acids 73:419-422(2005) [PubMed] [Europe PMC] [Abstract]