SET Domain Containing Protein 7 (SETD7)

SET7; SET7/9; Set9; KMT7; Lysine N-methyltransferase 7; Histone H3-K4 methyltransferase SETD7; Histone-lysine N-methyltransferase SETD7

SPN	L530
HGNC	30412
MGI	1920501
PubMed	21855806
RGD	1586346
UniProt	Q8WTS6
Wiki	SETD7

Methylation of histone H3 at lysine-9 (K9) by SUV39H1 and the subsequent recruitment of heterochromatin protein-1 (HP1) is linked to gene silencing. In addition to K9, H3 methylation also occurs at K4, K27, and K36.

SET7 methylates H3-K4 in vitro and in vivo and that methylation of H3-K4 and methylation of H3-K9 inhibit each other. Furthermore, H3-K4 methylation and H3-K9 methylation by SET7 and SUV39H1, respectively, were found to have differential effects on subsequent histone acetylation by p300. This study provided a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription.Set9 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site.

Reference

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Mol. Cell 8:1207-1217(2001) [PubMed] [Europe PMC] [Abstract]

"Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation."
Genes Dev. 16:479-489(2002) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

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DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cascade of distinct histone modifications during collagenase gene activation."
Mol. Cell. Biol. 23:1808-1816(2003) [PubMed] [Europe PMC] [Abstract]

"Gene-specific modulation of TAF10 function by SET9-mediated methylation."
Mol. Cell 14:175-182(2004) [PubMed] [Europe PMC] [Abstract]

"Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription."
J. Biol. Chem. 280:36244-36253(2005) [PubMed] [Europe PMC] [Abstract]

"Repression of p53 activity by Smyd2-mediated methylation."
Nature 444:629-632(2006) [PubMed] [Europe PMC] [Abstract]

"Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures."
J. Am. Chem. Soc. 128:1272-1278(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and functional analysis of the histone methyltransferase SET7/9."
Cell 111:105-115(2002) [PubMed] [Europe PMC] [Abstract]

"The active site of the SET domain is constructed on a knot."
Nat. Struct. Biol. 9:833-838(2002) [PubMed] [Europe PMC] [Abstract]

"Structure and catalytic mechanism of the human histone methyltransferase SET7/9."
Nature 421:652-656(2003) [PubMed] [Europe PMC] [Abstract]

"Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet."
EMBO J. 22:292-303(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of p53 activity through lysine methylation."
Nature 432:353-360(2004) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the methylation site specificity of SET7/9."
Nat. Struct. Mol. Biol. 13:140-146(2006) [PubMed] [Europe PMC] [Abstract]