Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)

SPN	K903
HGNC	15983
MGI	98956
PubMed	24254835
RGD	1308057
UniProt	P56704
Wiki	WNT3A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT3A is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. WNT3A encodes a deduced 352-amino acid protein containing an N-linked glycosylation site and residues conserved among members of the WNT family. The WNT3A protein shares 84.9% sequence identity with human WNT3 .

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Hu01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Hu01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Hu01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Hu01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Hu01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Mu01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Mu01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Mu01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Mu01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Mu01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Ra01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Ra01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Ra01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Ra01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Ra01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Ca01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Ca01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Ca01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Ca01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Ca01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Po01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Po01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Po01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Po01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Po01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Bo01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Bo01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Bo01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Bo01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Bo01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Rb01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Rb01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Rb01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Rb01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Rb01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPK903Mo01	Recombinant Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAK903Mo01	Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IP.
Antibodies	PAK903Mo01	Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	WB; IHC; ICC; IF.
Assay Kits	CLK903Mo01	CLIA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	CLIA assay for Antigen Detection
Assay Kits	ELK903Mo01	ELISA Kit for Wingless Type MMTV Integration Site Family, Member 3A (WNT3A)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region."
Biochem. Biophys. Res. Commun. 284:1168-1175(2001) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]

"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells."
Cell 125:509-522(2006) [PubMed] [Europe PMC] [Abstract]

"Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]

"WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification."
J. Cell Sci. 123:3357-3367(2010) [PubMed] [Europe PMC] [Abstract]

"APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex."
Nature 464:1043-1047(2010) [PubMed] [Europe PMC] [Abstract]

"Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling."
Cell. Signal. 23:837-848(2011) [PubMed] [Europe PMC] [Abstract]

"Disulfide bond requirements for active wnt ligands."
J. Biol. Chem. 289:18122-18136(2014) [PubMed] [Europe PMC] [Abstract]

"Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine."
Nat. Chem. Biol. 10:61-68(2014) [PubMed] [Europe PMC] [Abstract]

"Notum deacylates Wnt proteins to suppress signalling activity."
Nature 519:187-192(2015) [PubMed] [Europe PMC] [Abstract]