A Disintegrin And Metalloprotease 33 (ADAM33)
C20orf153; Disintegrin and metalloproteinase domain-containing protein 33
ADAM33 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.The 813-amino acid human protein shares 70% identity with the mouse protein. ADAM33 has a domain organization identical to that of previously reported members of the ADAM family, and contains the typical zinc-binding consensus sequence in the metalloprotease domain and a pattern of cysteine localization in the EGF-like domain that is typical of an EGF-like motif. The human protein shows 44% identity with Xenopus ADAM13, 40% with human ADAM19 , and 39% with human ADAM12.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Hu01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Hu01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Hu01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Hu01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Hu01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Mu01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Mu01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Mu01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Mu01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Mu01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Ra01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Ra01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Ra01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Ra01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Ra01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Ca01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Ca01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Ca01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Ca01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Ca01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Po01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Po01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Po01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Po01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Po01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Bo01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Bo01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Bo01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Bo01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Bo01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Rb01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Rb01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Rb01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Rb01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Rb01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK863Mo01 | Recombinant A Disintegrin And Metalloprotease 33 (ADAM33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK863Mo01 | Monoclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IP. |
| PAK863Mo01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 33 (ADAM33) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK863Mo01 | CLIA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | CLIA assay for Antigen Detection |
| ELK863Mo01 | ELISA Kit for A Disintegrin And Metalloprotease 33 (ADAM33) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity."
Gene 282:227-236(2002) [PubMed] [Europe PMC] [Abstract]
"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness."
Nature 418:426-430(2002) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"ADAM33 haplotypes are associated with asthma in a large Australian population."
Eur. J. Hum. Genet. 14:1027-1036(2006) [PubMed] [Europe PMC] [Abstract]
"Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort."
Thorax 64:381-387(2009) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the catalytic domain of human ADAM33."
J. Mol. Biol. 335:129-137(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]