PR Domain Containing Protein 14 (PRDM14)

PR domain zinc finger protein 14

SPN	K728
HGNC	14001
MGI	3588194
PubMed	18194669
UniProt	Q9GZV8

The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM14, are often involved in transcriptional regulation. PRDM14 gene encodes a deduced 571-amino acid protein that is 68% identical to the mouse ortholog.

Introduction of PRDM14 into cancer cells with normally low endogenous PRDM14 enhanced cell growth and reduced their sensitivity to various chemotherapeutic drugs. In contrast, siRNA knockdown of PRMD14 induced apoptosis in breast cancer cells and increased their chemotherapeutic drug sensitivity. Little, if any, expression of PRMD14 was detected in normal tissues. PRMD14 may be an ideal therapeutic target for the treatment of breast cancer.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Gene amplification and overexpression of PRDM14 in breast cancers."
Cancer Res. 67:9649-9657(2007) [PubMed] [Europe PMC] [Abstract]

"A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity."
Nature 468:316-320(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]