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Wingless Type MMTV Integration Site Family, Member 5A (WNT5A)

WNT5A is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.In the presence of a chemokine gradient, this Wnt-mediated receptor-actin-myosin polarity structure accumulates asymmetrically at the cell periphery, where it triggers membrane contractility and nuclear movement in the direction of membrane retraction. The process requires endosome trafficking, is associated with multivesicular bodies, and is regulated by Wnt5a through the small guanosine triphosphates Rab4 and RhoB.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Hu01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Hu01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Hu01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Hu01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Hu01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Mu01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Mu01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Mu01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Mu01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Mu01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Ra01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Ra01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Ra01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Ra01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Ra01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Ca01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Ca01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Ca01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Ca01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Ca01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Po01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Po01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Po01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Po01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Po01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Bo01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Bo01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Bo01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Bo01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Bo01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Rb01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Rb01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Rb01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Rb01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Rb01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK511Mo01 Recombinant Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK511Mo01 Monoclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IP.
PAK511Mo01 Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) WB; IHC; ICC; IF.
Assay Kits CLK511Mo01 CLIA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) CLIA assay for Antigen Detection
ELK511Mo01 ELISA Kit for Wingless Type MMTV Integration Site Family, Member 5A (WNT5A) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
Genomics 18:249-260(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Wnt-5a has tumor suppressor activity in thyroid carcinoma."
Oncogene 24:2144-2154(2005) [PubMed] [Europe PMC] [Abstract]

"The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
J. Biol. Chem. 282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]

"WNT5A mutations in patients with autosomal dominant Robinow syndrome."
Dev. Dyn. 239:327-337(2010) [PubMed] [Europe PMC] [Abstract]