Call Now

Linker For Activation Of T-Cells Family, Member 2 (LAT2)

WBSCR15, WBSCR5; WSCR5, HSPC046, LAB, NTAL; Williams-Beuren Syndrome Chromosome Region 5; Linker For Activation Of B Cells; Non-T Cell Activation Linker

LAT2 is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.Sequence analysis predicted that human WBSCR5 is a 243-amino acid nuclear protein, only 48% identical to the mouse sequence, that contains no known motifs. Northern blot analysis detected strong expression of a 1.9-kb transcript in peripheral blood leukocytes, placenta, and lung, with lower expression in spleen, heart, brain, liver, and pancreas.NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Phosphorylation of NTAL was strongest in the presence of LCK, ZAP70, SYK, or LYN.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Hu01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Hu01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Hu01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Hu01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Hu01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Mu01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Mu01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Mu01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Mu01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Mu01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Ra01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Ra01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Ra01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Ra01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Ra01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Ca01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Ca01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Ca01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Ca01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Ca01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Po01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Po01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Po01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Po01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Po01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Bo01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Bo01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Bo01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Bo01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Bo01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Rb01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Rb01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Rb01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Rb01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Rb01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK505Mo01 Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK505Mo01 Monoclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IP.
PAK505Mo01 Polyclonal Antibody to Linker For Activation Of T-Cells Family, Member 2 (LAT2) WB; IHC; ICC; IF.
Assay Kits CLK505Mo01 CLIA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) CLIA assay for Antigen Detection
ELK505Mo01 ELISA Kit for Linker For Activation Of T-Cells Family, Member 2 (LAT2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome."
Cytogenet. Cell Genet. 90:285-290(2000) [PubMed] [Europe PMC] [Abstract]

"Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23."
Mamm. Genome 11:890-898(2000) [PubMed] [Europe PMC] [Abstract]

"Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling."
J. Exp. Med. 196:1617-1626(2002) [PubMed] [Europe PMC] [Abstract]

"LAB: a new membrane-associated adaptor molecule in B cell activation."
Nat. Immunol. 4:117-123(2003) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation."
Blood 104:207-214(2004) [PubMed] [Europe PMC] [Abstract]

"The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB."
J. Biol. Chem. 279:11229-11235(2004) [PubMed] [Europe PMC] [Abstract]

"Transmembrane adaptor molecules: a new category of lymphoid-cell markers."
Blood 107:213-221(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]