Translocase Of Outer Mitochondrial Membrane 70A (TOMM70A)

TOM70A; Mitochondrial precursor proteins import receptor; Mitochondrial import receptor subunit TOM70; Translocase of outer membrane 70 kDa subunit

SPN	K486
HGNC	11985
MGI	106295
PubMed	10582581
RGD	1303049
UniProt	O94826
Wiki	TOMM70A

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.TOMM70A is 29% identical to the mitochondrial precursor protein import receptor of Neurospora crassa. RT-PCR analysis detected ubiquitous expression of KIAA0719, with relatively weak expression in pancreas, testis, and spleen.the cytosolic chaperones HSP90 and HSP70 dock onto a specialized tetratricopeptide domain in the import receptor TOMM70 at the outer mitochondrial membrane. This interaction served to deliver a set of preproteins to the receptor for subsequent membrane translocation dependent on the HSP90 ATPase. Disruption of the chaperone/TOMM70 recognition inhibited the import of these preproteins into mitochondria.

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