Serine/Threonine Kinase 24 (STK24)

MST3; MST3B; STK3; STE20; STE20-Like Kinase 3; Sterile 20-Like Kinase 3; Mammalian STE20-like protein kinase 3

SPN	K439
HGNC	11403
MGI	2385007
PubMed	22782892
RGD	1561742
UniProt	Q9Y6E0
Wiki	STK24

STK24 shares 69% amino acid identity with STK25 and is a member of the GCK subfamily of STE20-like proteins. Northern blot analysis revealed ubiquitous expression of a 2.0-kb STK24 transcript, with highest levels detected in heart, skeletal muscle, and pancreas. Western blot analysis detected a 52-kD STK24 protein in all cell lines tested.MST3B encodes a predicted 443-amino acid protein. RT-PCR and Northern blot analyses revealed that expression of the 2.5-kb MST3B transcript is restricted to brain; Western blot analysis confirmed the brain-specific expression. In situ hybridization analysis showed that MST3B is widely expressed in different brain regions, with high levels in hippocampus, cerebral cortex, and hypothalamus, and moderate levels in geniculate nucleus and thalamic nucleus.

Reference

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J. Biol. Chem. 272:28695-28703(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase."
J. Biol. Chem. 275:2513-2519(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Caspase activation of mammalian sterile 20-like kinase 3 (Mst3)."
J. Biol. Chem. 277:34367-34374(2002) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3."
FEBS Lett. 572:41-45(2004) [PubMed] [Europe PMC] [Abstract]

"Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3."
J. Inorg. Biochem. 99:1306-1313(2005) [PubMed] [Europe PMC] [Abstract]

"Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3."
Mol. Cell. Biol. 25:11019-11029(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST."
J. Biol. Chem. 281:38405-38417(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation."
Biosci. Rep. 29:405-415(2009) [PubMed] [Europe PMC] [Abstract]

"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways."
Nat. Neurosci. 12:1407-1414(2009) [PubMed] [Europe PMC] [Abstract]

"Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway."
Int. J. Biochem. Cell Biol. 42:98-105(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Structures of human MST3 kinase in complex with adenine, ADP and Mn2+."
Acta Crystallogr. D 66:145-154(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]