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Dickkopf Related Protein 4 (DKK4)

All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis detected no expression of DKK4, but RT-PCR analysis detected DKK4 expression in cerebellum, T-cell, esophagus, and lung cDNA libraries. Western blot analysis showed that DKK4 is secreted as 40-, 30- to 32-, and 15- to 17-kD proteins; these proteins were not significantly affected by N-glycanase treatment. N-terminal sequence analysis of the different forms suggested that DKK4 is proteolytically processed, possibly by intracellular furin-type proteases. Functional analysis determined that DKK4 blocks Xenopus Wnt8, Wnt3a, and Wnt2b, but not Dsh or Fz8, induction of a secondary axis in frog embryos, indicating that DKKs antagonize WNT function upstream of WNT receptors.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Hu01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Hu01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Hu01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Hu01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Hu01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Mu01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Mu01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Mu01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Mu01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Mu01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Ra01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Ra01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Ra01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Ra01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Ra01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Ca01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Ca01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Ca01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Ca01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Ca01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Po01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Po01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Po01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Po01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Po01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Bo01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Bo01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Bo01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Bo01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Bo01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Rb01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Rb01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Rb01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Rb01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Rb01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK002Mo01 Recombinant Dickkopf Related Protein 4 (DKK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK002Mo01 Monoclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IP.
PAK002Mo01 Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4) WB; IHC; ICC; IF.
Assay Kits CLK002Mo01 CLIA Kit for Dickkopf Related Protein 4 (DKK4) CLIA assay for Antigen Detection
ELK002Mo01 ELISA Kit for Dickkopf Related Protein 4 (DKK4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Functional and structural diversity of the human Dickkopf gene family."
Gene 238:301-313(1999) [PubMed] [Europe PMC] [Abstract]

"Human Dickkopf as well as DAN family members, Cerberus and Gremlin, are preferentially expressed in the epithelial malignant cell lines."
J. Biochem. Mol. Biol. Biophys. 3:239-242(1999)

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Function and biological roles of the Dickkopf family of Wnt modulators."
Oncogene 25:7469-7481(2006) [PubMed] [Europe PMC] [Abstract]