Cytochrome P450 3A7 (CYP3A7)
CP37; P450-HFLA; Cytochrome P450,Family 3,Subfamily A,Polypeptide 7
CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.CYP3A7 is expressed in placental and endometrial microsomes as a 51.5-kD protein that increases dramatically from the first to the second trimester of pregnancy.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Hu01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Hu01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Hu01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Hu01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Hu01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Mu01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Mu01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Mu01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Mu01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Mu01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Ra01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Ra01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Ra01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Ra01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Ra01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Ca01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Ca01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Ca01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Ca01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Ca01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Po01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Po01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Po01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Po01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Po01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Bo01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Bo01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Bo01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Bo01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Bo01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Rb01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Rb01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Rb01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Rb01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Rb01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK001Mo01 | Recombinant Cytochrome P450 3A7 (CYP3A7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK001Mo01 | Monoclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IP. |
| PAK001Mo01 | Polyclonal Antibody to Cytochrome P450 3A7 (CYP3A7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK001Mo01 | CLIA Kit for Cytochrome P450 3A7 (CYP3A7) | CLIA assay for Antigen Detection |
| ELK001Mo01 | ELISA Kit for Cytochrome P450 3A7 (CYP3A7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450."
J. Biochem. 105:161-163(1989) [PubMed] [Europe PMC] [Abstract]
"The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons."
Gene 260:13-23(2000) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene."
Pharmacogenetics 11:111-121(2001) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family."
Arch. Biochem. Biophys. 268:144-151(1989) [PubMed] [Europe PMC] [Abstract]
"Isolation of a new human fetal liver cytochrome P450 cDNA clone: evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers."
Arch. Biochem. Biophys. 272:219-225(1989) [PubMed] [Europe PMC] [Abstract]