Cell Division Cycle Protein 25B (CDC25B)

CDC25HU2; M-phase inducer phosphatase 2; Dual specificity phosphatase Cdc25B

SPN	J960
HGNC	1726
MGI	99701
PubMed	23160377
RGD	621500
UniProt	P30305
Wiki	CDC25B

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2.

CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. In vitro, p38 binds and phosphorylates CDC25B at serines 309 and 361, and CDC25C at serine-216; phosphorylation of these residues is required for binding to 14-3-3 proteins.

Reference

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New Biol. 3:959-968(1991) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?"
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Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

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Nature 411:102-107(2001) [PubMed] [Europe PMC] [Abstract]

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Oncogene 21:7630-7641(2002) [PubMed] [Europe PMC] [Abstract]

"Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function."
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"Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."
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Nat. Cell Biol. 6:884-891(2004) [PubMed] [Europe PMC] [Abstract]

"CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis."
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"MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."
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