Cluster Of Differentiation 8b (CD8b)
CD8B1; CD8 Antigen,Beta Polypeptide 1; T-cell surface glycoprotein CD8 beta chain
The T-cell differentiation antigen CD8 is a glycoprotein present at the surface of thymocytes and T lymphocytes that recognizes antigenic peptides in the context of the class I major histocompatibility complex (MHC) molecules. In the human, the CD8 antigen is a heterodimeric product of the association of an alpha (CD8A) and a beta chain (CD8B).CD8 is a T-cell glycoprotein expressed only in cytotoxic T cells that recognize antigen in context with class I major histocompatibility antigens. Antibodies against CD8 can block the killing activity of these cells, the inhibition occurring at the level of target cell adhesion. Mouse CD8 consists of 2 distinct chains, Ly-2 (Cd8a) and Ly-3 (Cd8b1); rat CD8, called Ox-8, also has 2 chains. Human CD8 was thought to be made up of only 1 chain in mature T cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Hu01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Hu01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Hu01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Hu01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Hu01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Mu01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Mu01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Mu01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Mu01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Mu01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Ra01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Ra01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Ra01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Ra01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Ra01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Ca01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Ca01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Ca01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Ca01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Ca01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Po01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Po01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Po01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Po01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Po01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Bo01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Bo01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Bo01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Bo01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Bo01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Rb01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Rb01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Rb01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Rb01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Rb01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPJ952Mo01 | Recombinant Cluster Of Differentiation 8b (CD8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAJ952Mo01 | Monoclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IP. |
| PAJ952Mo01 | Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLJ952Mo01 | CLIA Kit for Cluster Of Differentiation 8b (CD8b) | CLIA assay for Antigen Detection |
| ELJ952Mo01 | ELISA Kit for Cluster Of Differentiation 8b (CD8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A second subunit of CD8 is expressed in human T cells."
EMBO J. 7:3433-3439(1988) [PubMed] [Europe PMC] [Abstract]
"The human Lyt-3 molecule requires CD8 for cell surface expression."
EMBO J. 7:3465-3470(1988) [PubMed] [Europe PMC] [Abstract]
"A second chain of human CD8 is expressed on peripheral blood lymphocytes."
J. Exp. Med. 168:1993-2005(1988) [PubMed] [Europe PMC] [Abstract]
"Recent duplication of the two human CD8 beta-chain genes."
J. Immunol. 148:1919-1927(1992) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Transcriptional diversity at the duplicated human CD8 beta loci."
Eur. J. Immunol. 23:320-326(1993) [PubMed] [Europe PMC] [Abstract]