Bcl2 Like Protein 11 (BCL2L11)

BOD; BimL; BimEL; BIM; Bcl2-interacting mediator of cell death

SPN	J872
HGNC	994
MGI	1197519
PubMed	23064249
RGD	628774
UniProt	O43521
Wiki	BCL2L11

BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.

Reference

"Bim: a novel member of the Bcl-2 family that promotes apoptosis."
EMBO J. 17:384-395(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family."
FEBS Lett. 509:135-141(2001) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim."
Cancer Res. 62:2976-2981(2002) [PubMed] [Europe PMC] [Abstract]

"Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis."
Mol. Cell. Biol. 22:3577-3589(2002) [PubMed] [Europe PMC] [Abstract]

"Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis."
Int. J. Biochem. Cell Biol. 36:1554-1561(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas."
Apoptosis 12:1691-1701(2007) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors."
Mol. Cancer Ther. 3:1281-1288(2004) [PubMed] [Europe PMC] [Abstract]

"Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak."
Science 315:856-859(2007) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
J. Biol. Chem. 286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract]

"CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."
PLoS ONE 7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the degradation of Mcl-1 induced by BH3 domains."
Proc. Natl. Acad. Sci. U.S.A. 104:6217-6222(2007) [PubMed] [Europe PMC] [Abstract]

"Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim."
FEBS Lett. 582:3590-3594(2008) [PubMed] [Europe PMC] [Abstract]