Defensin Beta 126 (DEFb126)

ESP13.2; C20orf8; DEFB-26; Epididymal secretory protein 13.2

SPN	J254
HGNC	15900
MGI	3045368
PubMed	22710670
RGD	708352
UniProt	Q9BYW3
Wiki	DEFB126

DEFb126 belongs to the beta-defensin family. High-level and epididymis-specific expression. The innate immune system includes antimicrobial peptides that protect multicellular organisms from a diverse spectrum of microorganisms. beta-Defensins comprise one important family of mammalian antimicrobial peptides. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms.

DEFb126 is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey.

Reference

"The novel epididymal secretory protein ESP13.2 in Macaca fascicularis."
Biol. Reprod. 61:965-972(1999) [PubMed] [Europe PMC] [Abstract]

"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]