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RIO Kinase 1 (RIOK1)

RRP10; Serine/threonine-protein kinase RIO1

RIOK1 includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. RioK1 and pICln bind to PRMT5 in a mutually exclusive fashion. This results in a PRMT5-WD45/MEP50 core structure that either associates with pICln or RioK1 in distinct complexes. RioK1 functions in analogy to pICln as an adapter protein by recruiting the RNA-binding protein nucleolin to the PRMT5 complex for its symmetrical methylation. The exclusive interaction of PRMT5 with either pICln or RioK1 thus provides the first mechanistic insight into how a methyltransferase can distinguish between its substrate proteins.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Hu01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Hu01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Hu01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Hu01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Hu01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Mu01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Mu01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Mu01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Mu01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Mu01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Ra01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Ra01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Ra01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Ra01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Ra01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Ca01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Ca01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Ca01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Ca01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Ca01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Po01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Po01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Po01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Po01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Po01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Bo01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Bo01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Bo01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Bo01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Bo01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Rb01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Rb01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Rb01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Rb01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Rb01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH865Mo01 Recombinant RIO Kinase 1 (RIOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH865Mo01 Monoclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IP.
PAH865Mo01 Polyclonal Antibody to RIO Kinase 1 (RIOK1) WB; IHC; ICC; IF.
Assay Kits CLH865Mo01 CLIA Kit for RIO Kinase 1 (RIOK1) CLIA assay for Antigen Detection
ELH865Mo01 ELISA Kit for RIO Kinase 1 (RIOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]