Leucine Rich Repeat Containing Protein 4B (LRRC4B)

HSM; LRIG4; NGL-3; Netrin-G3 ligand; Leucine-Rich Repeats And Immunoglobulin-Like Domains 4

SPN	H463
HGNC	25042
MGI	3027390
PubMed	19285470
RGD	1307121
UniProt	Q9NT99

LRRC4B is a synaptic adhesion protein. It regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and LAR regulates excitatory synapse formation in a bidirectional manner.

LRRC4 are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. Mature LRRC4 family members are type I transmembrane proteins with an extracellular region that contains nine LRRs, a C2-type Ig-like domain, and a Thr-rich segment. LRRC4 family members share ~55% aa identity, but each recognizes different ligands. LRRC4 and LRRC4C recognize Netrin-G2 and Netrin-G3, respectively, while LRRC4B recognizes the receptor tyrosine phosphatases LAR/PTPRF, PTPR delta and PTPR sigma.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Hu01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Hu01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Hu01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Hu01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Hu01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Mu01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Mu01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Mu01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Mu01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Mu01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Ra01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Ra01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Ra01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Ra01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Ra01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Ca01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Ca01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Ca01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Ca01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Ca01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Po01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Po01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Po01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Po01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Po01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Bo01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Bo01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Bo01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Bo01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Bo01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Rb01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Rb01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Rb01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Rb01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Rb01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPH463Mo01	Recombinant Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAH463Mo01	Monoclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IP.
Antibodies	PAH463Mo01	Polyclonal Antibody to Leucine Rich Repeat Containing Protein 4B (LRRC4B)	WB; IHC; ICC; IF.
Assay Kits	CLH463Mo01	CLIA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	CLIA assay for Antigen Detection
Assay Kits	ELH463Mo01	ELISA Kit for Leucine Rich Repeat Containing Protein 4B (LRRC4B)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]