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T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT)

VSIG9; VSTM3; V-Set And Immunoglobulin Domain Containing 9; V-Set And Transmembrane Domain Containing 3

TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
The predicted 244-amino acid TIGIT protein has a single Ig domain, followed by a type I transmembrane domain and a single intracellular immunoreceptor tyrosine-based inhibitory motif. It shares 88%, 67%, and 58% amino acid identity with its rhesus, dog, and mouse homologs, respectively.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Hu01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Hu01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Hu01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Hu01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Hu01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Mu01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Mu01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Mu01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Mu01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Mu01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Ra01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Ra01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Ra01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Ra01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Ra01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Ca01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Ca01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Ca01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Ca01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Ca01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Po01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Po01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Po01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Po01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Po01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Bo01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Bo01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Bo01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Bo01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Bo01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Rb01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Rb01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Rb01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Rb01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Rb01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG678Mo01 Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG678Mo01 Monoclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IP.
PAG678Mo01 Polyclonal Antibody to T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) WB; IHC; ICC; IF.
Assay Kits CLG678Mo01 CLIA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) CLIA assay for Antigen Detection
ELG678Mo01 ELISA Kit for T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]

"Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering."
Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404(2012) [PubMed] [Europe PMC] [Abstract]