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Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2)

BPIFA2; PSP; C20orf70; BPI fold-containing family A member 2; Parotid secretory protein

SPLUNC2 antibodies identified a number of distinct protein bands in saliva, whilst immunohistochemical analysis demonstrated protein expression in serous cells of the major salivary glands and in the ductal lumens as well as in cells of minor mucosal glands. Antibodies directed against distinct epitopes of the protein yielded different staining patterns in both minor and major salivary glands. The gene undergoes alternative splicing using two 5' non-coding exons, suggesting that the gene is regulated by alternative promoters. Comprehensive RACE analysis using salivary gland RNA as template failed to identify any additional exons. SPLUNC2 is subject to N-glycosylation. Multiple SPLUNC2 isoforms are found in the oral cavity and suggest that these proteins may be differentially regulated in distinct tissues where they may function in the innate immune response.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Hu01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Hu01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Hu01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Hu01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Hu01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Mu01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Mu01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Mu01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Mu01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Mu01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Ra01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Ra01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Ra01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Ra01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Ra01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Ca01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Ca01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Ca01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Ca01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Ca01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Po01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Po01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Po01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Po01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Po01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Bo01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Bo01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Bo01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Bo01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Bo01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Rb01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Rb01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Rb01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Rb01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Rb01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG527Mo01 Recombinant Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG527Mo01 Monoclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IP.
PAG527Mo01 Polyclonal Antibody to Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) WB; IHC; ICC; IF.
Assay Kits CLG527Mo01 CLIA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) CLIA assay for Antigen Detection
ELG527Mo01 ELISA Kit for Short Palate, Lung And Nasal Epithelium Carcinoma Associated Protein 2 (SPLUNC2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein."
Arch. Oral Biol. 59:302-309(2014) [PubMed] [Europe PMC] [Abstract]