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Dermokine (DMKN)

Epidermis-specific secreted protein SK30/SK89

Dermokine is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This protein has been identified by Matsui et al (2004) who also suggested that this protein is a cytokine. The protein is expressed by keratinocytes in the spinous layer of the epidermis and is expressed strongly in granular keratinocytes . The protein has been found to be expressed also in tubular epithelial cells of the kidney, hepatocytes, lung macrophages, endothelial cells, acinar cells of the pancreas, smooth muscle cells, pancreatic islet cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Hu01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Hu01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Hu01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Hu01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Hu01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Mu01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Mu01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Mu01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Mu01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Mu01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Ra01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Ra01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Ra01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Ra01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Ra01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Ca01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Ca01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Ca01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Ca01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Ca01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Po01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Po01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Po01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Po01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Po01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Bo01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Bo01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Bo01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Bo01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Bo01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Rb01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Rb01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Rb01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Rb01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Rb01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Mo01 Recombinant Dermokine (DMKN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Mo01 Monoclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IP.
PAG302Mo01 Polyclonal Antibody to Dermokine (DMKN) WB; IHC; ICC; IF.
Assay Kits CLG302Mo01 CLIA Kit for Dermokine (DMKN) CLIA assay for Antigen Detection
ELG302Mo01 ELISA Kit for Dermokine (DMKN) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1."
Genomics 84:384-397(2004) [PubMed] [Europe PMC] [Abstract]

"The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location."
J. Invest. Dermatol. 126:503-506(2006) [PubMed] [Europe PMC] [Abstract]

"Dermokine: an extensively differentially spliced gene expressed in epithelial cells."
J. Invest. Dermatol. 127:1622-1631(2007) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]