Amy1 Associated Protein Expressed In Testis (AAT1)

MAATS1; AAT1alpha; MYCBP-binding protein; MYCBP/AMY-1-associated testis-expressed protein 1

SPN	G031
HGNC	24010
MGI	2443598
PubMed	1482685
UniProt	Q7Z4T9

The longest variant, AAT1-alpha, encodes a deduced 98-amino acid protein. The shorter transcripts, AAT1-beta and AAT1-gamma, encode identical proteins that correspond to the 31 C-terminal amino acids of AAT1-alpha. Western blot analysis of mouse testis detected endogenous Aat1-alpha at an apparent molecular mass of 10.8 kD. AAT1 was expressed in all mouse, rat, and human spermatogenesis-related tissues and cell lines examined. Expression was also detected in all cell lines of non-testis origin examined. In situ hybridization and immunohistochemical analysis of mouse testis detected Aat1 during all stages of spermatogenesis and in Leydig cells.Aat1 was also detected in the neck region of mature sperm. AAT1 colocalized with AMY1 in mitochondria in transfected human and mouse cells.

Reference

"AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase."
J. Biol. Chem. 277:45480-45492(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure and characterization of AAT-1 isoforms."
Biol. Pharm. Bull. 28:898-901(2005) [PubMed] [Europe PMC] [Abstract]