Autophagy Related Protein 16 Like Protein 1 (ATG16L1)

WDR30

SPN	F707
HGNC	21498
MGI	1924290
PubMed	23973919
UniProt	Q676U5
Wiki	ATG16L1

Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.

The deduced 607-amino acid protein has a calculated molecular mass of 68.2 kD and shares 90% identity with one of the mouse Atg16l1 isoforms. All 4 ATG16L1 isoforms have an N-terminal coiled-coil domain, and the 3 longest isoforms have 7 C-terminal WD repeats. The shortest isoform has only 3 C-terminal WD repeats.

Reference

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