Response Gene To Complement 32 (RGC32)
RGCC; C13orf15; Regulator of cell cycle RGCC
RGC32is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. Detected in brain, heart and liver. Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Hu01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Hu01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Hu01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Hu01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Hu01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Mu01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Mu01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Mu01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Mu01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Mu01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Ra01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Ra01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Ra01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Ra01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Ra01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Ca01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Ca01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Ca01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Ca01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Ca01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Po01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Po01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Po01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Po01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Po01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Bo01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Bo01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Bo01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Bo01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Bo01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Rb01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Rb01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Rb01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Rb01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Rb01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPF476Mo01 | Recombinant Response Gene To Complement 32 (RGC32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAF476Mo01 | Monoclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IP. |
| PAF476Mo01 | Polyclonal Antibody to Response Gene To Complement 32 (RGC32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLF476Mo01 | CLIA Kit for Response Gene To Complement 32 (RGC32) | CLIA assay for Antigen Detection |
| ELF476Mo01 | ELISA Kit for Response Gene To Complement 32 (RGC32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase."
J. Biol. Chem. 277:502-508(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Overexpression of RGC-32 in colon cancer and other tumors."
Exp. Mol. Pathol. 78:116-122(2005) [PubMed] [Europe PMC] [Abstract]
"RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest."
Oncogene 26:1110-1121(2007) [PubMed] [Europe PMC] [Abstract]
"RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells."
J. Biol. Chem. 284:9426-9432(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells."
PLoS ONE 6:E28638-E28638(2011) [PubMed] [Europe PMC] [Abstract]