Cytochrome P450 3A1 (CYP3A1)

CYPIIIA1; Cytochrome P450-PCN1

SPN	A906
PubMed	21718287
UniProt	P04800

Thymoquinone protected against renal I/R-induced damage through an antioxidant mechanism as well as the decrease of CYP3A1 and SSAT gene expression.

Thymoquinone treatment caused the reversal of I/R-induced changes in MDA as well as GST and SOD activity. Moreover, I/R caused a significant rise in creatinine and alanine aminotransferase serum levels. CYP3A1 mRNA expression was induced significantly by I/R in both liver and kidney tissues compared with sham group. Thymoquinone reduced significantly this increase. I/R caused induction of mRNA expression of spermidine/spermine N-1-acetyl-transferase (SSAT), a catabolic enzyme that participates in polyamine metabolism, in liver and kidney tissues. Thymoquinone reduced SSAT mRNA expression significantly in liver and markedly in kidney.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Hu01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Hu01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Hu01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Hu01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Hu01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Mu01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Mu01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Mu01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Mu01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Mu01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Ra01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Ra01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Ra01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Ra01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Ra01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Ca01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Ca01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Ca01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Ca01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Ca01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Po01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Po01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Po01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Po01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Po01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Bo01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Bo01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Bo01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Bo01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Bo01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Rb01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Rb01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Rb01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Rb01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Rb01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPA906Mo01	Recombinant Cytochrome P450 3A1 (CYP3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAA906Mo01	Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IP.
Antibodies	PAA906Mo01	Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1)	WB; IHC; ICC; IF.
Assay Kits	CLA906Mo01	CLIA Kit for Cytochrome P450 3A1 (CYP3A1)	CLIA assay for Antigen Detection
Assay Kits	ELA906Mo01	ELISA Kit for Cytochrome P450 3A1 (CYP3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family."
J. Biol. Chem. 260:7435-7441(1985) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel CYP3A1 allelic variant: analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone."
Arch. Biochem. Biophys. 293:147-152(1992) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms."
J. Biochem. 107:718-725(1990) [PubMed] [Europe PMC] [Abstract]

"Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats."
Arch. Biochem. Biophys. 301:345-354(1993) [PubMed] [Europe PMC] [Abstract]

"Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes."
Proc. Natl. Acad. Sci. U.S.A. 89:2145-2149(1992) [PubMed] [Europe PMC] [Abstract]

"Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development."
Arch. Biochem. Biophys. 298:715-725(1992) [PubMed] [Europe PMC] [Abstract]